Ácido úrico como factor pronóstico de dicapacidad neurológica y/o mortalidad en la enfermedad cerebrovascular isquémica aterotrombótica

Abstract

Introduction: The cerebral vascular pathology is the most frequent inside the neurological illnesses, evidence exists where the sharp elevations of the uric acid increase the disbility risk and mortality in the ischemic aterotrombotic vascular disease brain. Objective: To determine the relationship among the level of uric acid to the entrance, the neurological disability and/or the mortality in patient with diagnostic of ischemic aterotrombotic vascular disease brain. Material and Methods: Was carried out a prospective analytic observational study of cases and controls in patient with diagnostic of ischemic aterotrombotic vascular disease brain that were hospitalized by urgency in the hospital "Martires del 9 de Abril" during the period of January of the 2016 to March of the 2018. They were formed 2 groups: group case with patients deceaseds (n = 40) and group control with not died patients (n = 60). Results: The multivariad analysis of binary logistical regression identified as factor presage of mortality to the variable: uric acid to the high entrance (p: 0.015; OR: 1.01; IC: 1.01-1.02) and the scale of NIHSS with their states of important deficit (p: 0.049; OR: 6.0; IC: 1.76-2.36) and serious deficit (p: 0.031; OR: 2.0; IC: 1.39-2.86). Conclusions: The relationship among the level of uric acid is based on the prediction of neurological disability and/or of mortality in the sharp phase of an ischemic aterotrombotic vascular disease brain, associated to the scale of NIHSS. The dependence of the patients changes when the levels of high uric acid are presented to the entrance, with regard to the index of Barthel. The AVAD establishes a profile smaller than overlife, according to the patient's state in the sharp phase.