Mecanismos fisiopatológicos de la tolerancia a la isquemia en el sistema nervioso central

Abstract

The brain is one of the organs of the human body most sensitive to ischemia, that’s why it acquires endogenous mechanisms
to protect itself and recover against harmful stimuli. Ischemic tolerance is the brain’s adaptation to ischemia when exposed for the first time to any injury that is below the cell damage threshold. In recent decades, the molecular pathways and potential benefits of pre- and post-conditioning have been studied, representing a target for the treatment of patients with acute brain injury; however, the strategies that have been experimented have not demonstrated safety in humans and require a follow-up of systematic investigations to address their efficacy.