Cirugía guiada por radio-fluorescencia concomitante en glioma de alto grado. Estudio Cohorte

Abstract

Glioblastoma Multiforme is the most frequent primary malignant CNS tumor in adult’s. Multimodal therapy (surgery, radiotherapy, chemotherapy) achieved a median survival of 14 to 16 months, two years to the 26-33% and less than 5% to the five years. The gross total resection of glioma is directly proportional to the Increase of the survival. MIBI or sestamibi is a wide readiness to the rich flow of photons, which improves the detection of pathological uptake with gamma probe; these physical properties make the election of this radiotracer to radio guided surgery. The fluorescein sodium (FS) is a water-soluble organic coloring substance used in the vascular circulation exam of the eye. We carried out the report of eleven cases with high grade glioma to demonstrate the Radio-Fluro-guided Surgery utility (RFG). We can achieve gross total resections without bigger deficit. Conclusion. The RFG technique demonstrated utility in the gross total tumor resection, diminishing the residual tumor without surgery increasing complexity and surgical times. In our study does not evidence of adverse effects for the administration of MIBI and FS.